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Treatments

PGT-SR

Pre-implantation genetic testing for chromosomal structural rearrangements (PGT-SR) tests for issues with chromosomes of your embryos that might cause developmental defects or recurrent miscarriage.

It aims to identify embryos that are unaffected to improve the chances of a healthy pregnancy with IVF.

With over 35 years of experience, our fertility specialists and embryologists use the latest technologies and fertility treatments to help you make informed decisions in your fertility treatment.

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What is PGT-SR?

Pre-implantation genetic testing (PGT) is a type of embryo testing to check for genetic or chromosomal issues before they’re used in IVF treatment.  

PGT-SR looks for structural changes in the chromosomes in your embryos to determine the best ones for transfer. It can also test for aneuploidy – where an embryo has an extra or missing chromosome entirely.  

Chromosomes are the packages of DNA within the cells of our body. Changes like deletions, duplications or inversions can cause miscarriage or developmental defects in children that are born. 

These changes can be inherited or happen spontaneously.  

PGT-SR can be used if you’re at high risk of passing on a structural rearrangement to your child or have experienced multiple miscarriages caused by chromosomal abnormality. 

This test has helped many parents have healthy children by choosing unaffected embryos for transfer during IVF treatment.  

TFP Oxford Fertility is one of the selected IVF units that provides NHS England-funded PGT-SR treatment. 

What's the difference between PGT-M and PGT-SR?

While PGT-SR tests for structural changes in chromosomes, PGT-M tests for single gene mutations which cause specific genetic conditions. NHS funding for both PGT-SR and PGT-M is available at our fertility clinic in Oxford for people at risk of passing on a genetic condition to their children.

Learn more about PGT-M. 

A third type of test, called PGT-A, tests for an abnormal number of chromosomes in the embryo (aneuploidy). This is offered to patients who’ve had recurrent miscarriages or who are a little older.

Learn more about PGT-A

Types of chromosomal structural rearrangements

There are different types of chromosomal rearrangements (also known as translocations):  

  • Inversion – one chromosome is affected where a segment is flipped upside down  

  • Reciprocal translocation – segments of genetic material are swapped between two chromosomes  

  • Robertsonian translocation – two chromosomes join together to create one long one, resulting in 45 total chromosomes rather than the normal 46 

These structural rearrangements often result in extra or missing material in an embryo, called an unbalanced rearrangement, but they can also be balanced. 

You can lead a perfectly healthy life with a balanced rearrangement.  

However, even if you have a balanced rearrangement, your embryos are at risk of inheriting an unbalanced rearrangement when you try to conceive.  

Many people only find out they are a carrier of structural rearrangements through testing for fertility difficulties or recurrent miscarriage. 

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As part of your personalised treatment plan with us, you’ll have access to a fertility counsellor.  

They’re here to help you navigate your fertility journey and what to expect from your treatment. 

For IVF with PGT-SR, a genetic counselling service is also available with one session included in the cost. They can help you understand the impact of any chromosomal abnormalities you may carrier and the risks associated with passing these onto a child.  

We’re here to reassure you, answer your questions, and give you the emotional support you need every step of the way. 

How much does PGT-SR testing cost?

If you have been referred for PGT-M by the NHS, you may be eligible for treatment at TFP Oxford Fertility.

If you are eligible, we can secure funding and take you through the steps of PGT-SR treatment. 

You will be eligible for NHS funding if either the male or female partner or egg or sperm donor is found to have a translocation.

If you are ineligible for funding, our price list aims to give you a clear view of the cost of PGT-SR, to allow you to make informed financial planning.

Read about ways to pay for your treatment.

Work up and genetic counselling

Non-refundable; Includes DNA reference collection and development of unique test that lasts for 2 years

PGT-SR

£1700

PGT-SR

Pre-implantation genetic testing for structural rearrangements (PGT-SR) includes biopsy and testing and excludes production, freezing, storage and transfer of embryos (see below for cycle charges).

1 embryo

£770

2 embryos

£1,320

3 embryos

£1,870

4 embryos

£2,310

5 embryos

£2,750

6 embryos

£3,190

Additional Analysis (per embryo)

£385

Cycle packages

To create the embryos for testing and to transfer embryos once screened.

TFP freeze all and transfer cycle

Please see main clinic pricelist

TFP frozen embryo transfer cycle

Please see main clinic pricelist

Thaw and refreeze

For patients who undertake genetic testing after their embryos have been frozen. Includes thaw and re-freeze of embryo(s) to be tested.

Thaw and refreeze per embryo

£250

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