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Treatments

PGT-M

Pre-implantation genetic testing for monogenic disorders (PGT-M) can be used if you have a genetic condition that you’re worried about passing onto your child.

Monogenic disorders are genetic disorders caused by mutations in a single gene, for example, cystic fibrosis or Huntington's disease.

With over 35 years of experience, our fertility specialists and embryologists use the latest technologies and fertility treatments to help you make informed decisions in your fertility treatment.

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What is PGT-M?

Pre-implantation genetic testing (PGT) tests embryos to check for genetic problems before they’re used in IVF treatment.

Previously known as pre-implantation genetic diagnosis (PGD), PGT-M tests for specific conditions caused by single gene mutations, such a cystic fibrosis or Huntington’s disease.

It can be used if you’re at high risk of passing on a genetic condition to your child.

PGT-M has helped many parents have healthy children by choosing embryos unaffected by the genetic condition for transfer during IVF treatment.

TFP Oxford Fertility is one of the selected IVF units that provides NHS England-funded PGT-M treatment.

What does PGT-M test for?

PGT-M can test for over 1,700 genetic conditions approved by the HFEA (the UK fertility regulator), including:

  • Cystic fibrosis

  • Duchenne muscular dystrophy

  • Haemophilia

  • Huntington’s

  • Sickle cell disease 

The HFEA lists the conditions that are approved for testing based on the risk of passing it on to a child and the seriousness of the symptoms.

If a condition is not currently on the list, we can apply to the HFEA for approval on your behalf as a licensed PGT-M provider.

PGT-M success rates

NHS data shows one in three cycles of IVF with PGT-M will result in a baby. At TFP Fertility, on average 53% of frozen embryo transfers that have undergone PGT-M result in a live birth.

However, there are many factors that can affect your fertility including age and other conditions.

It’s also possible that no healthy embryos are available for transfer to continue the IVF treatment cycle.

This could be because:

  • No embryos are suitable for biopsy testing

  • No embryos are suitable for transfer as they are tested and found to all be affected by the genetic condition. Your fertility consultant will discuss your particular case with you and explain your chances of success with PGT-M

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Fertility counselling and support

As part of your personalised treatment plan with us, you’ll have access to a fertility counsellor. 

They’re here to help you navigate your fertility journey and what to expect from your treatment.  

For IVF with PGT-M, a genetic counselling service is also available with one session included in the cost. Our counsellors will help you understand the impact of any chromosomal abnormalities you may carry and the risks associated with passing these onto a child.

We’re here to reassure you, answer your questions, and give you the emotional support you need every step of the way. 

How much does PGT-M testing cost?

If you have been referred for PGT-SR by the NHS, you may be eligible for treatment at TFP Oxford Fertility.

If you are eligible, we can secure funding and take you through the steps of PGT-SR treatment. If you are ineligible for funding, our price list aims to give you a clear view of the cost of PGT-SR, to allow you to make informed financial planning.

Read about ways to pay for your treatment.

Work up and genetic counselling

Non-refundable; Includes DNA reference collection and development of unique test that lasts for 2 years

PGT-M

£2700

PGT-M

Pre-implantation genetic testing for monogenic diseases (PGT-M) includes biopsy and testing and excludes production, freezing, storage and transfer of embryos (see below for cycle charges).

1 embryo

£770

2 embryos

£1,320

3 embryos

£1,870

4 embryos

£2,310

5 embryos

£2,750

6 embryos

£3,190

Additional Analysis (per embryo)

£385

Cycle packages

To create the embryos for testing and to transfer embryos once screened.

TFP freeze all and transfer cycle

Please see main clinic pricelist

TFP frozen embryo transfer cycle

Please see main clinic pricelist

Thaw and refreeze

For patients who undertake genetic testing after their embryos have been frozen. Includes thaw and re-freeze of embryo(s) to be tested.

Thaw and refreeze per embryo

£250

FAQs

What’s the difference between PGT-A and PGT-M?

While PGT-A tests for an abnormal number of chromosomes in the embryo, PGT-M tests for specific genetic disorders caused by mutations in a single gene.

PGT-M is used if one or both parents are at risk of passing on a genetic condition to their baby.

TFP Oxford Fertility is a selected IVF units that provides NHS England-funded PGT-M treatment.

Learn more about PGT-M

How long do PGT-M testing take?

It takes roughly four weeks from the time of biopsy of embryos to receiving the genetic results.  It’s an additional step during IVF treatment after the fertilisation stage and before embryo transfer to the womb. 

What is the PGT-M process?

After fertilisation, one of our experienced embryologists carefully performs a biopsy on each blastocyst (an embryo that has grown into a ball of cells) to take a sample of cells.  

The sample is tested at a specialist laboratory to the highest standards.  

The embryos are frozen after biopsy while the test is carried out. Embryos that are unaffected by the gene mutation of interest are chosen for transfer to continue your IVF cycle. 

Learn more about the PGT process here. 

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