New studies in the reproductive medicine have shown that, when a “mild endometrium irritation” occurs in a cycle prior to an IVF (e.g. in the course of a hysteroscopy which is sometimes carried out before an IVF in order to determine the uterine cavity), the chances of nidation in the two following cycles are increased.
Cleary chemical messengers are released due to these mild irritations, which promote nidation. Metaphorically speaking, a seed has more chance of growing if it is planted in a slight groove in the ground and doesn’t just land on unprepared soil.
This effect can also be achieved by a small "micro-curettage" . This is a small procedure that can be carried out at the clinic without anaesthesia. A small “tube” (called Pipelle®) is inserted into the uterus which makes this little “roughening”. The procedure takes approximately ten minutes and is mostly pain-free. You are able to leave the clinic immediately after the procedure.
The best time to undergo a nidation curettage is in the first half cycle for an assisted reproductive technologies attempt (the effect lasts for two months – so when the IVF is not carried out straight away in the next cycle, it is also not a problem).
The procedure is particularly effective after an unsuccessful IVF with unsuccessful implantation. It can however also be carried out before the first IVF attempt.
It makes good sense to combine the nidation curettage in the cycle prior to IVF with a nidation rinse, in particular in the cases of unsuccessful prior attempts.