Clomifen lead to an increased distribution of the
gonadotropin detachment hormone in the pituitary gland. This leads to an increase of FSH – the Follicle Stimulating Hormone. FSH stimulates the oocyte's growth in the ovary. In some isolated cases, there have been side effects including hot flushes and sweating. One of the drug's biggest disadvantages is that the uterine mucosa doesn't develop as well as one would desire. TFP only uses Clomifen in a few isolated cases.
Precursor of the genetically produced FSH, hMG is a combination of urinary FSH and urinary LH. hMG was the first gonadotropin preparation used to stimulate the ovaries. It is still used because it is comparatively cheap and the results from using this drug are excellent.
These drugs are used to prevent ovulation - "down regulation". The ovulation needs to be prevented because the eggs are to be extracted from the oocytes (puncture) during IVF treatment.
This form of "down regulation" is used in our clinic in 90% of our patients. When using these drugs, we also use drugs to block the pituitary gland's function immediately.
Biotechnologically extracted FSH, just like the FSH produced by the pituitary glands, causes a stimulation of the ovaries and leads to increased egg maturation. The ovaries' response to this hormone depends on the dosage and varies from case to case.
Progesterone and other methods used to assist the luteal phase are used after the puncture of the ovaries. They ensure that a fertilised egg has the optimal conditions to allow a pregnancy to persist. They need to be inserted into the vagina on the evening of the puncture day. From the following day, they should be inserted according to your personal stimulation timetable (until the eighth pregnancy week).
are used following the puncture day according to your personal stimulation timetable (until the eighth pregnancy week).
at least 0.4mg should be taken daily beginning at least one week before the commencement of stimulation.
Additional drugs such as Aprednisolon and Glucophage should only be taken on the advice of the doctor at the KinderWunschKlinik!