The implantation of the embryo into the uterus of the mother is a very complex process. In order to avoid rejection of the embryo, an immune tolerance against the embryo must develop. The seminal plasma (ejaculate without sperm) appears to have an active role to play in this process. The implantation of an embryo requires a complex interplay of the messengers of seminal plasma, the cells of the uterus and the immune system.
The seminal plasma conditions the mother's immune response and causes an immune tolerance to the embryo. The seminal plasma also causes molecular and cellular changes in the lining of the uterus necessary for embryo implantation and development.
The seminal plasma thus has a crucial role in the preparation of the uterus for the embryo and probably in the implantation of the embryo as well as the formation of a stable and healthy pregnancy.
The seminal plasma (ejaculate without sperm) is mainly made up of the secretion from the seminal vesicale and 25% secretion from the prostate gland.
The seminal plasma also contains a variety of messenger substances such as interleukin and TGF. Its purpose is the growth of blood vessels and the promotion of inflammation. It also influences immunological reactions.
The ejaculate is divided by centrifugation into spermatozoa and seminal plasma. The sperm lies at the bottom of the tube. 0.5 - 0.1 ml of seminal plasma is syringed off. This is then injected through the cervix after follicle puncture or embryo transfer.This new procedure of flushing helps couples with repeated implantation complications to achieve a stable and healthy pregnancy!