The emergence of new life is subject to a strict time schedule. There is only a short space of time in which an embryo is able to successfully implant in the uterine lining (endometrium). In the case of fertility treatment, it is therefore desirable to implant the in-vitro generated embryos at the optimal time for nidation. An ERA test allows for a precise determination of the so-called implantation window: genetic testing of the uterine lining is used to determine its "receptivity". We also offer the ERA test at our TFP fertility clinics. Our fertility experts will gladly advise you personally as to whether the procedure is recommended for your individual diagnosis.
The build-up of the uterine lining over the course of one's cycle is hormonally controlled for the most part. When exactly the uterine lining is ready for implantation of the fertilised egg differs from woman to woman. The ERA procedure (endometrial receptivity array) examines a group of 238 genes in the uterine lining. The state of these genes provides information about the receptivity of the mucosa, i.e., its ability to facilitate successful implantation, on the day of the test. It is thus possible to determine on exactly which day of one's cycle the endometrium is ready for implantation or nidation.
1. Hormonal testing
In a natural cycle, the ERA test is performed seven days after the increase in the luteinising hormone (LH) in the woman's cycle. Alternatively, the cycle can be artificially controlled via targeted administration of hormones (HRT cycle with administration of oestrogen and progesterone). The biopsy is performed six days after starting to administer progesterone.
Using a plastic catheter, small tissue samples are taken from the uterus via the vagina. The procedure is quick and by and large painless.
3. Genetic testing
The tissue sample is sent to a specialist laboratory in Spain for genetic testing immediately after collection. If the genetic testing reveals that the tissue is receptive on the day of the biopsy, a personalised Embryo Transfer (pET) can be scheduled for one of the next cycles. Based on the result, the embryo transfer can be planned for the right day.
The ERA procedure is not a routine examination. The genetic testing in the specialist laboratory and the biopsy involve effort and expense. Our doctors in the TFP fertility clinic therefore recommend the ERA test first and foremost for women who have undergone repeated unsuccessful embryo transfers despite having good embryos and normal build-up of the mucosa. We would of course be happy to advise you personally on the details of the ERA procedure and on the prospects of success in your individual case – contact our clinic's team at any time.